Baseline left atrial reservoir strain provides independent and incremental prognostic value in predicting chemotherapy related cardiotoxicity
نویسندگان
چکیده
Abstract Background Currently, few baseline imaging biomarkers can predict chemotherapy induced cardiotoxicity (CTx). The early identification of CTx is critically important as it determines the prospect LV function recovery (1). Purpose We aimed to determine if left atrial (LA) reservoir strain (LAS) predictive CTx. Methods performed retrospective analysis SUCCOUR study, an international multicentre randomized controlled trial. was defined asymptomatic drop >10% in ventricular ejection fraction (LVEF) compared <55%. LAS using semi-automated speckling tracking LA four and two chamber views EchoPAC. Analysis at one year follow up. Cox proportional hazard analysis, c-statistics Akaike information criterion (AIC) statistical performed. Results After excluding 78 with inadequate images, 229 were included analysis. Most participants female (n=215, 94%), a mean age 54±12 years. Median up 1.02 years (IQR 0.98–1.07). A smoking history commonest cardiac risk factor (n=68, 30%). Breast cancer main type (n=205, 90%). 3D LVEF, global longitudinal (GLS), LAS, volume index (LAVI) 61±4%, 20.6±2.5%, 28.6±7.9%, 28±9ml/m2, respectively. Participants that developed had lower those did not (25.5±7.4% vs 29.0±7.9% respectively; p=0.027). At 1-year follow-up, 29 patients (13%) On univariable higher associated (HR 0.95, 95% CI 0.90–0.99; p=0.026) but other parameters including GLS (p=0.17). In nested models (Figure 1), adding significantly improved model's accuracy for clinical parameters. When added same showed improvements AIC score 1). Conclusion Baseline independent incremental predictor could be used stratification oncology who receive potentially cardiotoxic chemotherapy. Funding Acknowledgement Type funding sources: Private grant(s) and/or Sponsorship. Main source(s): GE Healthcare
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2022
ISSN: ['2634-3916']
DOI: https://doi.org/10.1093/eurheartj/ehac544.2566